![]() Low levels or no sperm exists in pre-ejaculate, although studies examined small samples of men. ![]() Pre-ejaculate also acts as a lubricant during sexual activity, and plays a role in semen coagulation. The vagina is normally acidic, so the deposit of pre-ejaculate before the emission of semen may change the vaginal environment to promote sperm survival. Pre-ejaculate neutralizes residual acidity in the urethra caused by urine, creating a more favorable environment for the passage of sperm. Pre-ejaculate fluid contains chemicals associated with semen, such as acid phosphatase, but other semen markers, such as gamma-glutamyltransferase, are absent. Some individuals do not produce any pre-ejaculate fluid, while others emit as much as 5 ml (0.18 imp fl oz 0.17 US fl oz). The amount of fluid that is issued varies widely among individuals. It is primarily produced by the bulbourethral glands ( Cowper's glands), with the glands of Littré (the mucus-secreting urethral glands) also contributing. The fluid is discharged from the urethra of the penis during arousal, masturbation, foreplay or at an early stage during sexual intercourse, some time before the individual fully reaches orgasm and semen is ejaculated.
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